⚡ The Ketone Supercharger Playbook

🔥 Ketones aren’t just fuel — they’re a whole metabolic toolkit. In his latest deep dive with Tim Ferriss, Dr. Dominic D’Agostino unpacked how to use exogenous ketones, MCT oil, fasting tricks, and smart supplementation to protect your brain, sharpen cognition, and even extend healthspan. This isn’t theory — Dom tests these protocols in NASA simulations, Navy SEAL training, and his own lab. Below you’ll find the most actionable takeaways, brand recommendations, and stacks you can put to work today.
🎧 Listen to the full episode here

🔑 Top Actionable Hacks

1. Ketone + MCT Stack (The Big One)

• 🥤 Combine exogenous ketones (BHB salts or esters) with MCT oil or powder.

• 🚀 This creates a multiplicative effect → higher, longer-lasting ketones vs either alone.

• 🧠 Use this for sharper cognition, clean energy, and fewer dips during fasts or long work sessions.

• 💡 Dom’s go-tos: KetoStart (BHB electrolytes) + Keto Brainz (MCT + Alpha-GPC + theanine).

2. Sardine Fasting

• 🐟 Eat 1–2 cans/day for 3–5 days. Keeps protein, omega-3s, and micronutrients while triggering fasting benefits like autophagy.

• ⚡ Pair with electrolytes (LMNT or KetoStart) to avoid “keto flu.”

3. Track Metabolic Health Smarter

• 📊 Use Keto-Mojo to track both glucose + ketones (with built-in Glucose Ketone Index).

• Aim for GKI of 1–4 during fasting or therapeutic ketosis.

4. Supplement Shortlist (Dom’s picks)

• 💪 Creatine monohydrate (Momentous, Nutricost) – 5–10g/day for brain + muscle.

• 🌞 Vitamin D – maintain 60–80 ng/mL.

• 🧬 Omega-3s – fish-forward diet or Nordic Naturals if supplementing.

• 🌙 Melatonin – Dom uses it beyond sleep for neuroprotection.

5. Lipid Management for Keto Folks

• ~30% of people hyperabsorb cholesterol → check ApoB & hs-CRP (better than LDL alone).

• If LDL is sky-high: Dom cut his ApoB in half with ezetimibe (Zetia).

⚠️ Note from the episode: chronic, heavy use of exogenous ketones may raise liver enzymes — worth keeping an eye on with bloodwork.

6. Mitochondrial & Mental Health Edge

• 🧪 NAD boosters like MIB-626 are in trials, but ketones themselves are mitochondrial rocket fuel.

• 🧩 Metabolic psychiatry is growing: apps like MetPsy explore keto for depression, bipolar, and anxiety.

🚀 Quick Action List

• ✅ Try the ketone + MCT stack for focus.

• ✅ Experiment with a 3-day sardine fast (add electrolytes).

• ✅ Get a Keto-Mojo meter → track GKI.

• ✅ Add creatine + omega-3s + vitamin D to your base stack.

• ✅ Watch ApoB + hs-CRP, not just LDL.

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